Pradefovir Mesylate Tablets Application Scope

Pradefovir Mesylate Tablets are an antiviral medication primarily used for the treatment of chronic hepatitis B virus (HBV) infection. It is a prodrug of adefovir, designed to improve liver-targeted delivery and reduce systemic toxicity. It works by inhibiting HBV DNA polymerase, thereby suppressing viral replication.

Pradefovir Mesylate Tablets Characteristics

Ingredients:
Active ingredient: Pradefovir Mesylate
Inactive ingredients: (Specific excipients may vary by manufacturer; consult the product leaflet for details.)
Properties:
Pradefovir Mesylate is a nucleotide analog with antiviral activity against hepatitis B virus. It is formulated as a tablet for oral administration.
Specification:
Available in strengths of [e.g.10 mg, 20 mg, 45 mg].
Packaging Specification:
Typically packaged in blister packs or bottles, containing [e.g., 10, 20, or 30 tablets per pack].
Storage:
Store at room temperature (15–30°C) in a dry place, protected from light and moisture.
Expiry Date:
Usually 24–36 months from the date of manufacture (check the packaging for the exact date).
Executive Standard:
Manufactured in compliance with [ GMP (Good Manufacturing Practices)].
Approval Number:
Based on the latest approval number
Date of Revision:
Based on latest revision date
Manufacturer:
Xi’an Gelan Xintong Pharmaceutical

Guidelines for the Use of Pradefovir Mesylate Tablets

Dosage and Administration:
- The recommended dose is [e.g.10 mg once daily].
- Administer orally with or without food.
- Dosage adjustments may be required for patients with renal impairment.
Adverse Reactions:
Common side effects may include:
- Nausea
- Headache
- Fatigue
- Elevated liver enzymes
- Rare but serious side effects may include renal toxicity or lactic acidosis.
Contraindications:
- Hypersensitivity to pradefovir mesylate or any of its components.
- Severe renal impairment without dose adjustment.
Precautions:
- Monitor renal function regularly during treatment.

Pradefovir Mesylate Tablets Interactions

Drug Interactions:
- Nephrotoxic drugs: Increased risk of renal toxicity when used with drugs like aminoglycosides or NSAIDs.
- Other antiviral agents: Potential for additive or synergistic effects.
- Drugs affecting renal function: Dosage adjustments may be required.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.