Hydroxylcamptothecine Injection Application Scope

Hydroxylcamptothecine is a chemotherapy drug used in the treatment of various cancers, particularly solid tumors and certain lymphomas. It is a topoisomerase I inhibitor, working by interfering with the DNA replication process in rapidly dividing cancer cells. By inhibiting topoisomerase I, it prevents the cancer cells from dividing and leads to their death. Hydroxylcamptothecine is often used in combination with other chemotherapy drugs to enhance therapeutic effects.

Hydroxylcamptothecine Injection Characteristics

Ingredients:
- Active Ingredient: Hydroxylcamptothecine
- Excipients: Includes stabilizers, buffers, and solvents for intravenous administration.
Properties:Hydroxylcamptothecine is a potent anticancer agent that interferes with DNA replication by inhibiting topoisomerase I, making it effective against certain solid tumors and hematologic cancers. It is administered intravenously and has cytotoxic effects on cancerous cells.
Specification:Available as 10 mg/mL or other concentrations for intravenous administration, typically provided in vials for clinical use.
Storage:Store at room temperature (between 15°C and 25°C), away from
Expiry Date:Typically 24 months from the manufacturing date, but please check specific product packaging for expiry.
Executive Standard:Meets regulatory standards as per FDA or other relevant authorities.
Approval Number:Approval number according to FDA or other relevant health authorities.
Manufacturer:Typically [Manufacturer Name], such as [Manufacturer].

Guidelines For The Use Of Hydroxylcamptothecine Injection

Dosage and Administration:

The usual dose of Hydroxylcamptothecine is based on body surface area (B5 to 10 mg/m² administered intravenously, typically in a 3-week cycle. It can be adjusted depending on the patient’s response and tolerability.
Hydration and pre-medication with antiemetics are often required to prevent nausea and vomiting.

Adverse Reactions:

Common side effects include nausea, vomiting, fatigue, bone marrow suppression, and hair loss.
Serious side effects may include severe diarrhea, liver toxicity, and neutropenia.

Medication Limitations

Contraindications:

Hypersensitivity to Hydroxylcamptothecine or any of its excipients.
Pregnancy and breastfeeding should be avoided unless deemed necessary by the physician due to potential teratogenic effects.

Precautions:

Monitor liver function and blood counts regularly during therapy.
Caution is advised in patients with renal impairment or those taking other chemotherapy drugs.

Hydroxylcamptothecine Injection Injection Interactions

Drug Interactions:

Hydroxylcamptothecine may interact withchemotherapy agents, especially those that affect bone marrow or liver function.
CYP450 inhibitors and inducers may affect the drug’s metabolism, requiring dose adjustments.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.