Paishuning (Senaparib) – Ovarian Cancer | HongKong DengYue Medicine

Senaparib Application Scope

Indication: Treatment of ovarian cancer in patients with germline or somatic BRCA-mutated advanced or recurrent disease.

SenaparibCharacteristics

• Ingredients: Senaparib (PARP inhibitor).

• Properties:​ Oral, small-molecule PARP inhibitor; blocks DNA repair in tumor cells, leading to cell death.

• Packaging Specification:​ 20 mg × 75 capsules/box

• Storage:​ Store at 20–25 °C, protect from moisture and light.

• Expiry Date: As printed on the package.

• Executive Standard: ​Per registered product quality standard.

• Approval Number: As indicated on label.

• Date of Revision: As printed on package insert.

• Manufacturer: Beigene / BeiGene Ltd.

Guidelines for the Use of Paishuning

• Dosage and Administration:

  • Recommended Dose: 20–30 mg/day (depending on regimen and patient tolerance).

  • Administration: Swallow capsules whole; do not chew or crush.

  • Missed Dose:​ Take as soon as remembered; do not double the next dose.

• Adverse Reactions:

  • Common Adverse Reactions: Nausea, vomiting, fatigue, anemia, thrombocytopenia, leukopenia, diarrhea, decreased appetite.

  • Serious Adverse Reactions: Myelosuppression (severe anemia, thrombocytopenia, neutropenia), secondary malignancies (rare), gastrointestinal toxicity, fatigue.

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• Contraindications:

  • Hypersensitivity to it or excipients.

  • Pregnancy and breastfeeding.

• Precautions:

  • Monitor blood counts regularly.

  • Adjust dose for hematologic toxicity.

  • Avoid live vaccines during treatment.

  • Contraception advised during and after therapy.

Senaparib Interactions

• CYP3A inhibitors/inducers may alter it exposure.

• Co-administration with other myelosuppressive agents may increase hematologic toxicity.

• Monitor concomitant drugs with narrow therapeutic index.

Note:

• If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
•  This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.