Vorinostat Application Scope

Zolinza is an oral histone deacetylase (HDAC) inhibitor that induces cell cycle arrest, differentiation, and apoptosis in malignant cells by altering gene expression.

Indications:

Cutaneous T-cell lymphoma (CTCL): For patients with progressive, persistent, or recurrent disease following at least two systemic therapies.

Vorinostat Characteristics

Ingredients: Active ingredient: Vorinostat
Excipients: microcrystalline cellulose, magnesium stearate, sodium starch glycolate, etc.
Properties: White to off-white capsules.
Packaging Specification: 100 mg capsules, bottles of 120.
Storage: Store at 20–25°C. Protect from moisture.
Expiry Date: As indicated on package (24–36 months).
Executive Standard: Enterprise/regulatory authority standard.
Approval Number: Per FDA/NMPA/EMA records.
Date of Revision: As listed in insert.
Manufacturer: Merck & Co., Inc.

Guidelines for the Use of Zolinza

Dosage and Administration:
- Recommended Dose: 400 mg orally once daily.
- Administration: Swallow whole with food.
- Missed Dose: Skip and take the next scheduled dose. Do not double dose.
Adverse Reactions:
- Common Adverse Reactions:
  - Fatigue
  - Nausea, diarrhea, anorexia
  - Thrombocytopenia, anemia
  - Weight loss
- Serious Adverse Reactions:
  - Pulmonary embolism, deep vein thrombosis
  - Severe thrombocytopenia or anemia
  - QT prolongation, cardiac events
  - Severe dehydration from GI toxicity
Contraindications:
- Hypersensitivity to Vorinostat or excipients.
- Pregnancy and breastfeeding.
Precautions:
- Monitor CBC, electrolytes, ECG.
- Use caution in patients with prior thromboembolic disease.
- Ensure adequate hydration.

Vorinostat Interactions

Caution with anticoagulants (↑ bleeding risk).
May interact with other HDAC inhibitors (↑ toxicity).
CYP substrate interactions possible.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.