Zoledronic Acid Injection Application Scope

Zoledronic Acid is a bisphosphonate used to treat bone-related conditions such as osteoporosis, Paget’s disease of bone, and bone metastases from cancer.

It works by inhibiting osteoclast-mediated bone resorption, helping to strengthen bones and reduce the risk of fractures. It is also used to treat hypercalcemia of malignancy, a condition where high calcium levels in the blood occur due to cancer.

Zoledronic Acid Injection Characteristics

Ingredients:
- Active Ingredient: Zoledronic Acid
- Excipients: Various excipients suitable for intravenous administration.
Properties:Zoledronic Acid is a bisphosphonate that binds to bone tissue, inhibiting the action of osteoclasts (cells that break down bone), leading to bone strength restoration and reduced risk of fractures or complications related to cancer-induced bone damage.
Specification:Typically available in 4 mg/5 mL and 5 mg/100 mL formulations for intravenous infusion.
Storage:Store at room temperature (between 20°C to 25°C) and protect from light.
Expiry Date:Typically 24 months from the date of manufacture, verify with specific product packaging.
Executive Standard:Meets regulatory standards established by FDA or local health authorities.
Approval Number:Approval details vary by region; please check the specific approval number.
Manufacturer:Manufactured by companies like Novartis, or other generic manufacturers.

Guidelines For The Use Of Zoledronic Acid Injection

Dosage and Administration:

The usual dose for osteoporosis is 5 mg administered as an intravenous infusion once a year, or based on doctor’s recommendations.
For bone metastases, hypercalcemia of malignancy, and Paget’s disease, the dose may vary based on patient needs, typically administered every 3-4 weeks depending on the condition being treated.
Infusion duration is typically 15 minutes.

Adverse Reactions:

Common side effects include fever, muscle aches, joint pain, and headache.
Serious side effects can include kidney toxicity, osteonecrosis of the jaw, and hypocalcemia (low calcium levels).

Medication Limitations

Contraindications:

Hypersensitivity to Zoledronic Acid or other bisphosphonates.
Pregnancy and lactation (unless prescribed under the risk-benefit assessment of the healthcare provider).

Precautions:

Ensure patients are hydrated prior to the infusion to reduce risk of kidney damage.
Monitor serum calcium levels and renal function throughout the treatment.

Zoledronic Acid Injection Interactions

Drug Interactions:

Calcium supplements and vitamin D may interact, requiring close monitoring of calcium levels.
Aminoglycosides (e.g., gentamicin) may enhance nephrotoxic effects when used concomitantly with Zoledronic Acid.
Loop diuretics may increase the risk of hypocalcemia during treatment.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine, HongKong Drug Wholesale Distributor. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.