Vigabatrin Powder For Oral Solution Application Scope

Vigabatrin is primarily used for the treatment of refractory complex partial seizures in patients who are not adequately controlled by other anticonvulsants.

It is also used as an adjunctive therapy in the treatment of infantile spasms (West syndrome) in infants and young children. Vigabatrin works by inhibiting the enzyme GABA transaminase, which increases levels of gamma-aminobutyric acid (GABA) in the brain, helping to control seizure activity.

Vigabatrin Powder For Oral Solution Characteristics

Ingredients:
- Active ingredient: Vigabatrin
- Excipients: Inactive ingredients such as stabilizers, sweeteners, and flavorings.
Properties:Vigabatrin is an anticonvulsant that works by irreversibly inhibiting GABA transaminase, an enzyme responsible for breaking down GABA. This leads to increased levels of GABA, a neurotransmitter that helps to control brain excitability and reduce seizure activity.
Specification:Available as a powder for oral solution with a typical concentration of 500 mg of Vigabatrin per sachet.
Storage:
- Store in a cool, dry place at room temperature (15°C to 30°C).
- Keep the container tightly closed and protect from light and moisture.
Expiry Date:Typically 24 months from the manufacturing date (check packaging for exact expiry).
Executive Standard:Meets FDA or other relevant regulatory body standards for antiepileptic drugs.
Approval Number:Specific approval details from the FDA or other regulatory bodies.
Manufacturer:commonly Lundbeck, Horizon Therapeutics, or similar manufacturers.

Guidelines For The Use Of Vigabatrin Powder For Oral Solution

Dosage and Administration:

The typical starting dose for refractory complex partial seizures is 500 mg per day, gradually increasing based on the patient’s response, with a usual maintenance dose of 3 grams per day.
For infantile spasms, the recommended dose is usually based on the infant’s weight, starting with 50 mg/kg/day, divided into two doses per day.
Oral solution should be mixed with water or other liquids as per the instructions on the packaging.

Adverse Reactions:

Common side effects include drowsiness, headache, irritability, and weight gain.
Serious side effects can include vision problems (e.g., peripheral vision loss), aggressive behavior, depression, and suicidal thoughts.
Long-term use can lead to potential damage to the retina, so regular eye exams are required.

Medication Limitations

Contraindications:

Hypersensitivity to Vigabatrin or any of the formulation components.
Contraindicated in patients with pre-existing visual field defects.

Precautions:

Patients using Vigabatrin should be monitored regularly for vision problems, particularly peripheral vision loss. Baseline and periodic eye exams are necessary.
Use with caution in patients with renal impairment, as Vigabatrin is primarily excreted by the kidneys.

Vigabatrin Powder For Oral Solution Injection Interactions

Drug Interactions:

Vigabatrin may interact with other anticonvulsants, increasing the risk of sedation or central nervous system depression.
It may also interact with drugs affecting renal function or those that impact GABAergic activity (e.g., benzodiazepines).

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine, China Drug Import and Export Wholesaler.
It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.