Calcium Leucovorin Application Scope

Calcium Leucovorin for Injection is indicated for:

Chemotherapy Rescue: Mitigates toxicity from high-dose methotrexate therapy in conditions like osteosarcoma.
Folic Acid Antagonist Overdose: Counteracts effects of inadvertent overdosages of folic acid antagonists.
Megaloblastic Anemia Treatment: Addresses megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible.
Colorectal Cancer Therapy: Enhances the efficacy of fluorouracil in the palliative treatment of advanced colorectal cancer.

tongao calcium leucovorin

Calcium Leucovorin Characteristics

Ingredients: Calcium Leucovorin
Properties: Sterile, preservative-free solution with a pH of 7.8
Packaging Specification: Available in single-dose vials containing 50 mg, 100 mg, 200 mg, or 350 mg
Storage: Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F)
Expiry Date: Refer to the packaging for specific expiration information
Executive Standard: USP (United States Pharmacopeia)
Approval Number: Refer to the FDA label for specific approval details
Date of Revision: Refer to the FDA label for the most recent revision date
Manufacturer: Produced by various pharmaceutical companies; refer to specific product labeling for details

Dosage and Administration:
- Recommended Dose: Dosing varies based on the indication and patient-specific factors. Refer to the prescribing information for detailed dosing guidelines.
- Administration: Administered via intravenous (IV) or intramuscular (IM) injection.
- Missed Dose: If a dose is missed, administer as soon as possible unless it’s close to the time of the next dose. Do not double doses.
Adverse Reactions:
- Common Adverse Reactions: Fever, nausea, vomiting, diarrhea, stomatitis, and fatigue.
- Serious Adverse Reactions: Hypersensitivity reactions, including anaphylactoid reactions and urticaria.
Contraindications:
- Pernicious anemia and other megaloblastic anemias secondary to vitamin B12 deficiency.
- Hypersensitivity to leucovorin calcium or any component of the formulation.
Precautions:
- Administration Route: Do not administer intrathecally; may be harmful or fatal if given intrathecally.
- Monitoring: Monitor serum methotrexate concentrations during therapy.
- Drug Interactions: Leucovorin calcium may enhance the toxicity of 5-fluorouracil.

5-Fluorouracil: Leucovorin calcium may enhance the toxicity of 5-fluorouracil.
Folic Acid: Large amounts of folic acid may counteract the antiepileptic effect of phenobarbital, phenytoin, and primidone and increase the frequency of seizures in susceptible pediatric patients.
Intrathecal Administration: Leucovorin calcium may reduce the efficacy of intrathecally administered methotrexate.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.