Tapinarof/Symbiox (Benvitimod Cream) – Plaque Psoriasis

Benvitimod Cream (Tapinarof) Application Scope

Used for the treatment of mild-to-moderate plaque psoriasis by modulating immune response and reducing skin inflammation.

Emerging studies support use in other inflammatory skin diseases.

Benvitimod Cream Characteristics

• Ingredients:
  Benvitimod (Tapinarof) 1%

  Properties:
  Non-steroidal, small-molecule AhR (aryl hydrocarbon receptor) modulator with anti-inflammatory and antioxidant effects.

  Packaging Specification:
  Usually supplied in 10g or 30g aluminum tubes (varies by market)

  Storage:
  Store below 25°C, protect from light and moisture.

  Expiry Date:
  Refer to packaging

  Executive Standard:
  [To be filled based on registration—e.g., Chinese Pharmacopoeia or FDA standards]

  Approval Number:
  H20193146 (China, 2019)

  Date of Revision:
  [Insert date]

  Manufacturer:
  Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd.

Guidelines for the Use of Benvitimod Cream

• Dosage and Administration: Apply a thin layer of 1% cream to affected areas once daily.

• Administration: Topical use only. Do not apply to broken skin, eyes, or mucous membranes.

• Missed Dose: Apply as soon as remembered. Skip if it’s almost time for the next dose.

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• Adverse Reactions:

  Common Adverse Reactions (≥5% and >3% higher than placebo):

  • Folliculitis

  • Contact dermatitis

  • Pruritus

  • Headache

  Serious Adverse Reactions:

  • Hypersensitivity reactions (rare)

  • Severe skin irritation in sensitive individuals

• Contraindications:

  Patients with known hypersensitivity to benvitimod or any excipients.

• Precautions:

  •  Skin Reactions: Discontinue if irritation or allergic reaction occurs.
  • Pregnancy and Lactation: Use only if clearly needed; consult physician.
  • Avoid Occlusive Dressings: Unless directed by physician.

Benvitimod Cream Interactions

• No major systemic drug interactions reported due to minimal systemic absorption. Avoid concurrent use with other topical agents on the same area unless prescribed.

Note:

• If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
•  This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.