Ryanodex Dantrolene Application Scope

Ryanodex (Dantrolene) is indicated for the treatment of malignant hyperthermia (MH), a rare but potentially life-threatening condition triggered by certain anesthetic agents during surgery.

It is used to rapidly reverse the hypermetabolic state induced by MH, characterized by a high fever, muscle rigidity, and acidosis. Dantrolene works by inhibiting the release of calcium from the sarcoplasmic reticulum in muscle cells, which helps to control the excessive muscle contractions and heat production in MH.

Ryanodex is also used to treat neuroleptic malignant syndrome (NMS), a condition associated with antipsychotic drug use.

Ryanodex Dantrolene Characteristics

Ingredients:
- Active ingredient: Dantrolene sodium
- Excipients: Sodium hydroxide, other stabilizers
Properties:Ryanodex is a muscle relaxant that works by inhibiting calcium release from muscle cells, reducing muscle rigidity, and preventing the hypermetabolic crisis seen in conditions like malignant hyperthermia.
Specification:Available as an injectable solution, typically in 20 mg/100 mL vials for intravenous administration.
Storage:Store at room temperature (between 20°C and 25°C), protected from light.
Expiry Date:Typically 36 months from the date of manufacture (check packaging for exact date).
Executive Standard:Meets FDA or local health authority standards for injectable drugs.
Approval Number:Approval from relevant regulatory authorities, such as FDA.
Manufacturer:Revance Therapeutics, Inc. or other licensed manufacturers.

Guidelines For The Use Of Ryanodex Dantrolene Moa

Ryanodex Dosage and Administration:

Malignant hyperthermia: Initial dose is 2.5 mg/kg body weight, administered as an IV bolus. Additional doses may be given if needed.
For neuroleptic malignant syndrome, dosing is typically based on the severity of symptoms and clinical judgment.

Dantrolene Side Effects:

Common side effects include drowsiness, muscle weakness, nausea, and diarrhea.
Serious side effects may include liver damage, respiratory depression, and cardiac arrhythmias.

Medication Limitations

Contraindications:

Dantrolene Sodium should not be used in patients with liver disease or active hepatic dysfunction.
Contraindicated in patients with known hypersensitivity to dantrolene or any component of the formulation.

Precautions:

Monitor liver function during treatment.
Caution should be exercised in patients with pulmonary, renal, or cardiovascular disorders.

Ryanodex Dantrolene Interactions

Drug Interactions:

Ryanodex may interact with calcium channel blockers, muscle relaxants, and other anesthetic agents.
Concomitant use with centrally acting muscle relaxants or benzodiazepines may increase the risk of respiratory depression and sedation.

Note:

If there is a new packaging for dantrolene sodium drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine, China Drug Import and Export Wholesaler.
It is only for internal discussion among medical staff and does not serve as a basis for medication.
For Ryanodex specific medication guidelines, please consult the attending physician.