Quinlock Ripretinib Application Scope

Quinlock (Ripretinib) is indicated for the treatment of advanced gastrointestinal stromal tumors (GIST) in patients who have received prior treatment with multiple kinase inhibitors.

Quinlock Ripretinib Characteristics

Ingredients:
- Ripretinib
Properties:
- Oral tyrosine kinase inhibitor targeting KIT and PDGFRA mutations.
Packaging Specification:
- 50 mg capsules per bottle (check local packaging specifics)
Storage:
- Store at room temperature, protected from moisture and light.
Expiry Date:
- See packaging label.
Executive Standard:
- Follow regulatory authority standards (FDA, EMA, etc.)
Approval Number:
- Refer to local regulatory approval.
Date of Revision:
- [To be filled based on the latest update]
Manufacturer:
- Deciphera Pharmaceuticals, LLC

Guidelines for the Use of Quinlock Ripretinib

Dosage and Administration:
- Recommended Dose: 150 mg orally twice daily (total 300 mg daily)
- Administration: Oral capsules, taken with or without food.
- *Missed Dose: If missed, take as soon as possible. Do not double dose.
Adverse Reactions: Common Adverse Reactions (≥5% and >3% higher than placebo):
- 🥱 Fatigue
- 🤢 Nausea
- 🩸 Decreased platelet count (thrombocytopenia)
- 🧑‍🦲 Alopecia (hair loss)
- 🔥 Palmar-plantar erythrodysesthesia (hand-foot syndrome)
- 🤒 Abdominal pain
- 💨 Diarrhea or constipation
- ⚡ Muscle pain (myalgia)
Serious Adverse Reactions:
- 🚨 Hypersensitivity reactions (rash, swelling, bronchospasm)
- 💔 Cardiac dysfunction (rare)
- 🚺 Embryo-fetal toxicity (avoid in pregnancy)
Contraindications:
- History of serious hypersensitivity to Ripretinib or any excipients.
Precautions:
- Monitor for hypersensitivity reactions; discontinue if severe.
- Monitor platelet counts and blood pressure regularly.
- Advise patients to avoid pregnancy during treatment and use effective contraception.

Quinlock Ripretinib Interactions

Avoid concomitant use with strong CYP3A inhibitors or inducers as they may affect Ripretinib levels.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
It is only for internal discussion among medical staff and does not serve as a basis for medication. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.