Proglycem Diazoxide Application Scope:

Diazoxide is primarily used to manage hyperinsulinemic hypoglycemia in neonates, children, and adults. It is indicated for the treatment of conditions where excessive insulin production leads to low blood sugar, such as in patients with nesidioblastosis or congenital hyperinsulinism. Additionally, it is used to manage certain types of hypertension, particularly in patients with malignant hypertension.

Proglycem Diazoxide Characteristics:

Ingredients: Diazoxide
Properties: Diazoxide is a potent vasodilator that works by inhibiting insulin release from pancreatic beta cells, thus preventing hypoglycemia. It also causes vascular smooth muscle relaxation, leading to blood pressure reduction.
Specification: Commonly available in 25 mg, 50 mg, or 100 mg tablet forms (exact specifications may vary based on the formulation).

Packaging Specification:

Typically supplied in 25 mg or 100 mg tablet forms. Packaging may vary based on the supplier (e.g., bottles containing 30 or 100 tablets).
Storage: Store at room temperature, away from moisture and heat. Keep out of reach of children.
Effective Period: Generally 24 months from manufacturing date (refer to packaging for specifics).
Approval Number: This would be specific to the country of regulation (e.g., FDA, EMA, or NMPA approval).
Manufacturer: This could be a pharmaceutical company such as Hikma Pharmaceuticals or any relevant manufacturer.

Guidelines For The Use Of Proglycem Diazoxide:

Dosage and Administration:
Diazoxide is typically administered orally. The recommended starting dose for hyperinsulinemic hypoglycemia is around 3–8 mg/kg/day, divided into 2–3 doses. For malignant hypertension, it is used in intravenous form at higher doses, administered under close medical supervision.
Adverse Reactions:
Common side effects may include fluid retention, edema, tachycardia, hyperglycemia, and headache. Rare but serious effects include pulmonary edema and cardiovascular events. Regular monitoring of electrolytes and blood pressure is recommended.

Medication Limitations

Contraindications:
- Contraindicated in patients with pheochromocytoma, diabetic ketoacidosis, or hyperglycemia that cannot be controlled.
- Should not be used in patients with heart failure or those who have demonstrated hypersensitivity to Diazoxide.
Precautions:
- Use with caution in patients with renal impairment, cardiac disease, or those at risk for fluid retention.
- Patients on Diazoxide should have their blood pressure and blood glucose levels monitored regularly.
- Be cautious of drug interactions with medications that affect blood sugar levels, such as insulin or sulfonylureas.

Proglycem Diazoxide Interactions

Drug Interactions:
- Diazoxide may interact with insulin or oral hypoglycemic agents, potentially leading to worsened hyperglycemia.
- It may also enhance the effect of antihypertensive drugs, which can lead to hypotension if used concurrently.
- Corticosteroids and diuretics may increase the risk of fluid retention.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.