Ozamode/Ozanimod Hydrochloride Capsules

Ozamode/Ozanimod Hydrochloride Capsules, the new and special drug, marketed under the brand name Zeposia, are primarily used for the treatment of relapsing forms of multiple sclerosis (MS) and moderately to severely active ulcerative colitis (UC) in adults.

Ozamode Hydrochloride Capsules Characteristics

• Ingredients:
  Active ingredient: Ozanimod Hydrochloride.
  Inactive ingredients: [Specific excipients not listed; refer to the manufacturer’s official prescribing information for details].
• Properties:
  Ozanimod is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds to S1P receptors, reducing lymphocyte migration into the central nervous system and inflamed tissues.
• Packaging Specification:
  Supplied in blister packs containing 7 or 30 capsules, depending on the prescribed dosage regimen.
• Storage:
  Store at room temperature, 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F).
• Expiry Date:
  Refer to the packaging for the expiration date.
• Executive Standard:
  Manufactured in compliance with Good Manufacturing Practices (GMP) and approved by relevant health authorities.
• Approval Number:
  [Specific approval number varies by country; refer to local regulatory information].
• Date of Revision:
  [Refer to the latest prescribing information for the most recent revision date].
• Manufacturer:
  Bristol-Myers Squibb Company.

• Ingredients:
  Active ingredient: Ozanimod Hydrochloride.
  Inactive ingredients: [Specific excipients not listed; refer to the manufacturer’s official prescribing information for details].
• Properties:
  Ozanimod is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds to S1P receptors, reducing lymphocyte migration into the central nervous system and inflamed tissues.

Guidelines For The Use Of Ozamode Hydrochloride Capsules

• How do you take hydrochloride capsules? Dosage and Administration:
  Initiate treatment with a 7-day titration:
  • Days 1-4: 0.23 mg once daily.
  • Days 5-7: 0.46 mg once daily.
  • Day 8 and onward: 0.92 mg once daily.
    Swallow capsules whole; do not crush or chew.
    Can be taken with or without food.
    Missed dose: If a dose is missed during the first 2 weeks of treatment, reinitiate the titration regimen.
• Adverse Reactions:
  Common side effects include headache, back pain, elevated liver enzymes, and hypertension.
  Serious adverse reactions may include infections, bradycardia, liver injury, and macular edema.
  Monitor patients for signs and symptoms of these conditions.

Medication Limitations

• Contraindications:
  • Recent (within the last 6 months) myocardial infarction, unstable angina, stroke, transient ischemic attack, or decompensated heart failure requiring hospitalization.
  • Severe untreated sleep apnea.
  • Concomitant use of monoamine oxidase inhibitors (MAOIs).
• Precautions:
  • Obtain a recent (within the last 6 months) complete blood count, liver function tests, and an electrocardiogram before initiating treatment.
  • Monitor blood pressure regularly during treatment.
  • Advise patients to report any visual disturbances promptly.
  • Counsel patients on the potential risk of infections and advise them to seek medical attention if they develop symptoms of infection.

Ozamode Hydrochloride Capsules Interactions

• Avoid concomitant use with strong CYP2C8 inhibitors (e.g., gemfibrozil) and inducers (e.g., rifampin).
• Caution with concurrent use of other immunosuppressive therapies due to additive immune system effects.
• Potential interaction with serotonergic and adrenergic drugs; avoid use with MAOIs.

Note: If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYueMed(登越药业). It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.