Nplate Romiplostim Application Scope

Nplate (Romiplostim) is used to treat immune thrombocytopenic purpura (ITP), a condition in which the immune system attacks platelets, leading to a low platelet count and increased risk of bleeding.

It is specifically indicated for chronic ITP in patients who have not responded to steroid therapy or other treatments such as immunoglobulins or splenectomy.

Nplate stimulates the production of platelets by mimicking the action of thrombopoietin (TPO), a natural hormone that helps regulate platelet production in the bone marrow.

Nplate Romiplostim Characteristics

Ingredients:
- Active ingredient: Romiplostim
- Excipients: Includes sodium chloride, sodium citrate, and water for injection.
Properties: Romiplostim is a recombinant thrombopoietin receptor agonist. It binds to the TPO receptor and stimulates the production of platelets in the bone marrow, increasing platelet counts in patients with ITP.
Specification: Nplate is available as a subcutaneous injection in 250 mcg vials.

Packaging Specification:

Ingredients: Each vial contains 250 mcg of romiplostim.
Properties: Romiplostim is in a lyophilized powder form, requiring reconstitution with the provided diluent before subcutaneous injection.
Specification: Available in single-use vials (250 mcg per vial).
Storage:
- Store the vials in a refrigerator at 2°C to 8°C (36°F to 46°F).
- Do not freeze.
Effective period: Shelf life is typically 36 months from the date of manufacture.
Approval Number: Refer to the FDA approval number or local regulatory approval for the product.
Manufacturer: Amgen Inc.

Guidelines For The Use Of Nplate Romiplostim

Dosage and Administration:
- The recommended starting dose for chronic ITP patients is 1 mcg/kg of body weight, administered as a subcutaneous injection once a week.
- The dose can be adjusted based on the patient’s platelet count. The dose range typically falls between 1–10 mcg/kg.
- Nplate is administered weekly, and therapy should be adjusted according to the patient’s response and platelet count.
Adverse Reactions:
- Common side effects include headache, fatigue, injection site reactions, and musculoskeletal pain.
- Serious side effects may include bone marrow fibrosis, thromboembolic events, and increased platelet counts leading to risk of clot formation.

Medication Limitations

Contraindications:
- Nplate should not be used in patients with hypersensitivity to romiplostim or any of its components.
- Not recommended for patients with active or uncontrolled bone marrow disorders.
Precautions:
- Monitoring of platelet counts is necessary, especially during the initial phases of treatment.
- Caution is advised in patients with a history of thrombosis or bone marrow disorders.
- Regular monitoring for signs of bone marrow fibrosis is recommended.

Nplate Romiplostim Interactions

Drug Interactions:
- No significant drug interactions have been identified, but caution should be exercised when used with medications affecting blood clotting, such as anticoagulants, as they may increase the risk of bleeding.
- Corticosteroids or other immunosuppressants may affect platelet counts, and dose adjustments may be necessary.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine, China Medicine Wholesaler. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.