Medroxyprogesterone Acetate Capsule Application Scope

Medroxyprogesterone Acetate is primarily used for the treatment of endometrial carcinoma, abnormal uterine bleeding, and as a contraceptive agent in the form of depot injection. The oral form, Medroxyprogesterone Acetate Capsules, is also used in hormone replacement therapy (HRT) to treat symptoms of menopause, such as hot flashes and night sweats, and to prevent endometrial hyperplasia in patients undergoing estrogen therapy.

Medroxyprogesterone Acetate Capsule Characteristics

Ingredients:
- Active Ingredient: Medroxyprogesterone Acetate
- Excipients: Various stabilizers and inactive ingredients used in the capsule formulation.
Properties:Medroxyprogesterone Acetate is a progestin, a synthetic form of the hormone progesterone, which regulates various reproductive functions. It is used in contraceptive treatments, hormone therapy for menopause, and certain types of cancer treatment like endometrial cancer.
Specification:Available in 2.5 mg, 5 mg, and 10 mg capsules.
Storage:Store at room temperature, away from moisture and heat.
Expiry Date:Typically 36 months from the manufacturing date, but check packaging for the exact expiry.
Executive Standard:Meets standards established by regulatory authorities such as the FDA or local health authorities.
Approval Number:The specific approval number for local markets.
Manufacturer:Manufactured by [Manufacturer Name], such as Pfizer, Pharmacia, or other recognized producers.

Guidelines For The Use Of Medroxyprogesterone Acetate Capsule

Dosage and Administration:

For endometrial cancer and abnormal uterine bleeding, the usual dosage is 5 to 10 mg daily, depending on the condition being treated.
For hormone replacement therapy, 2.5 mg daily may be recommended, or as advised by a healthcare provider.
The dosage can be adjusted based on individual patient needs, and this should be done under medical supervision.

Adverse Reactions:

Common side effects include headaches, weight changes, breast tenderness, and mood swings.
Serious side effects may include thromboembolic events, stroke, or breast cancer in prolonged use.

Medication Limitations

Contraindications:

Medroxyprogesterone Acetate should not be used in individuals with a history of breast cancer, thrombophlebitis, or liver disease.
It is also contraindicated in pregnancy and should be used with caution in breastfeeding women.

Precautions:

Regular breast exams, pap smears, and blood pressure monitoring should be conducted.
Caution is recommended for women with a history of depression, diabetes, or hypertension.

Medroxyprogesterone Acetate Capsule Interactions

Drug Interactions:

Enzyme inducers (e.g., rifampin) may reduce the effectiveness of Medroxyprogesterone Acetate.
Anticonvulsants (e.g., phenytoin) may also decrease its effectiveness.
CYP3A4 inhibitors could increase the concentration of Medroxyprogesterone in the bloodstream, requiring possible dose adjustments.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.