Ifosfamide For Injection Application Scope

Ifosfamide is a chemotherapy drug used primarily in the treatment of various types of cancer, including sarcomas, lymphomas, and testicular cancer. It is also sometimes used as part of combination therapy for solid tumours like breast cancer and ovarian cancer. Ifosfamide is an alkylating agent, that works by interfering with DNA replication in cancer cells, thereby preventing their growth and division.

Ifosfamide For Injection Characteristics

Ingredients:
- Active ingredient: Ifosfamide
- Excipients: Includes various stabilizers and inactive components for intravenous administration.
Properties:
- Ifosfamide is classified as an alkylating agent. It forms cross-links in DNA, which prevents cancer cells from replicating and induces cell death.
- It is administered intravenously and has a cytotoxic effect on rapidly dividing cells, making it effective for certain types of cancer.
Specification:Available as 500 mg and 1 g vials for intravenous injection.
Storage:Store at room temperature (between 20°C to 25°C), protected from light and moisture.
Expiry Date:Typically 36 months from the date of manufacture (verify with the packaging).
Executive Standard:Meets regulatory standards as per the FDA or other local health authority guidelines.
Approval Number:Specific approval details depending on the local regulatory body.
Manufacturer:such as Baxter, Bristol-Myers Squibb, or another pharmaceutical manufacturer.

Guidelines For The Use Of Ifosfamide For Injection

Dosage and Administration:

Adult Dosage: The typical dose of Ifosfamide ranges from 1 to 2.5 g/m² administered intravenously over a period of 1 hour, typically on days 1-5 in a chemotherapy regimen.
Children’s Dosage: Adjusted based on body surface area (BSA), weight, and specific treatment protocol.
Dosing schedules may vary based on the cancer type and treatment plan (often given with mesna to prevent hemorrhagic cystitis).

Adverse Reactions:

Common side effects include nausea, vomiting, fatigue, bone marrow suppression, and hair loss.
Serious side effects include hemorrhagic cystitis, liver toxicity, kidney toxicity, and central nervous system effects like encephalopathy or confusion.

Medication Limitations

Contraindications:

Known hypersensitivity to Ifosfamide or its components.
Severe renal impairment without proper dose adjustments.
Use with caution in pregnancy and lactation due to potential teratogenic effects.

Precautions:

Hydration and administration of mesna are essential to protect the bladder and prevent hemorrhagic cystitis.
Regular monitoring of kidney function, liver enzymes, and blood counts is recommended during therapy.

Ifosfamide For Injection Interactions

Drug Interactions:

Cisplatin: Increased nephrotoxicity risk when used together.
Phenytoin: May reduce the effectiveness of phenytoin as an anticonvulsant when used with Ifosfamide.
Cyclosporine: Potential for increased nephrotoxicity.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.