Gattex Teduglutide Application Scope

Gattex medication(Teduglutide) is a recombinant analog of human GLP-2 (glucagon-like peptide-2) used to treat short bowel syndrome (SBS) in adults and pediatric patients who have undergone intestinal surgery and require parenteral nutrition (PN). It is indicated for patients who are dependent on intravenous nutrition due to insufficient intestinal function.

Teduglutide works by promoting intestinal growth, improving nutrient absorption, and reducing the need for PN in SBS patients, which can significantly enhance the patient’s quality of life.

Gattex Teduglutide Characteristics

Ingredients:
- Active Ingredient: Teduglutide (Recombinant human GLP-2 analog)
- Excipients: Includes water for injection, phosphoric acid, and other stabilizers.
Properties:Teduglutide is a recombinant peptide hormone that mimics the action of GLP-2, a natural hormone that stimulates the growth and repair of the intestinal lining, enhancing nutrient absorption in the small intestine.
Specification:Available as Subcutaneous Injection in 5 mg/0.5 mL vials or prefilled syringes.
Packaging:Vials or prefilled syringes containing 5 mg/0.5 mL of teduglutide.
Storage:
- Store in a refrigerator at 2°C to 8°C.
- Do not freeze. Protect from light.
Effective Period:Typically 24 months from the date of manufacture, refer to packaging for the exact expiry date.
Approval Number:Refer to the local regulatory authority (e.g., FDA, EMA) for the approval number.
Manufacturer:Shire Pharmaceuticals (now part of Takeda).

Gattex Package Insert

Dosage and Administration:Adults and pediatric patients (≥1 year) with short bowel syndrome (SBS):
- The recommended Gattex dosing is 0.05 mg/kg of body weight, administered as a subcutaneous injection once daily.
- The treatment is usually continued for up to 12 months or longer, depending on patient response and clinical evaluation.
Gattex Side Effects
- Common side effects include abdominal pain, gastrointestinal disturbances (such as diarrhea, nausea, bloating), and headache.
- Rare but serious side effects include intestinal obstruction or ischemic bowel disease.

Gattex Medication Limitations

Contraindications:
- Gattex drug should not be used in patients with a history of intestinal obstruction, megaloblastic anemia, or known hypersensitivity to teduglutide or any excipients.
- Not recommended for patients with active malignancy or those at risk of intestinal perforation.
Precautions:
- Use with caution in patients with a history of gastrointestinal issues such as Crohn’s disease or ulcerative colitis.
- Monitoring for symptoms of intestinal obstruction is recommended during treatment.
- Periodically monitor for gastrointestinal complications, especially during the first few months of treatment.

Gattex Teduglutide Interactions

Gattex Drug Interactions:
- No major drug interactions have been identified with Teduglutide. However, caution is recommended when used with other medications that affect intestinal motility, absorption, or gastric function.
- Patients receiving parenteral nutrition (PN) should be closely monitored for changes in nutrient absorption.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.