Fomepizole Application Scope

Is indicated as an antidote for ethylene glycol (e.g., antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.

fomepizole

Characteristics

Ingredients: Each vial contains 1.5 g of fomepizole in 1.5 mL solution (1 g/mL).
Properties: Fomepizole is a competitive inhibitor of alcohol dehydrogenase, preventing the metabolism of ethylene glycol and methanol into toxic metabolites.
Specification: Injection, 1.5 g/1.5 mL (1 g/mL).
Packaging Specification: Supplied in clear glass vials containing 1.5 mL of solution.
Storage: Store at controlled room temperature, 20°C to 25°C (68°F to 77°F).
Expiry Date: Refer to the manufacturer’s labeling for specific expiration information.
Executive Standard: Manufactured in accordance with FDA-approved standards.
Approval Number: NDA 020815.
Date of Revision: Refer to the manufacturer’s labeling for the latest revision date.
Manufacturer: PAR Pharmaceutical, Inc.

Guidelines for the Use of Fomepizole

Dosage and Administration: Administer intravenously. The initial dose is 15 mg/kg, followed by 10 mg/kg every 12 hours for four doses, then 15 mg/kg every 12 hours thereafter. Adjust dosing during hemodialysis.
Adverse Reactions: Common side effects include headache, nausea, dizziness, increased drowsiness, and a bad or metallic taste.
Contraindications: Contraindicated in patients with a history of serious hypersensitivity reactions to fomepizole or other pyrazoles.
Precautions: Do not administer undiluted or by bolus injection due to the risk of venous irritation. Avoid using polycarbonate syringes or needles, as fomepizole can interact with polycarbonate materials.

Interactions

Drug Interactions: Fomepizole is metabolized by cytochrome P450 enzymes and can induce its own metabolism. Concurrent use with alcohol may decrease the elimination rate of both substances.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.