Eloxatin Oxaliplatin Application Scope

Eloxatin is indicated for the treatment of:

Adjuvant Treatment: Stage III colon cancer following complete resection of the primary tumor.
Advanced Colorectal Cancer: In combination with infusional fluorouracil and leucovorin.
eloxatin（oxaliplatin)

Eloxatin Oxaliplatin Characteristics

Ingredients: Oxaliplatin
Properties: White to almost white freeze-dried cake or powder
Packaging Specification: Vials containing 50 mg, 100 mg, or 200 mg of oxaliplatin
Storage: Store at 2–8°C (36–46°F); protect from light
Expiry Date: Please refer to the expiry date on the product’s packaging
Executive Standard: Comply with pharmacopeial standards applicable in the country
Approval Number: Refer to the FDA label for specific approval details
Date of Revision: Please refer to the latest official prescribing information for the most current revision date
Manufacturer: Sanofi (Sanofi-Aventis)

Guidelines for the Use of Eloxatin Oxaliplatin

Dosage and Administration:
- Recommended Dose:
  - Adjuvant Treatment: Administer every 2 weeks for up to 12 cycles or until unacceptable toxicity occurs.
  - Advanced Colorectal Cancer: Continue treatment until disease progression or unacceptable toxicity.
- Administration: For intravenous infusion only. It must be diluted in a 5% glucose solution. The infusion should last 2 to 6 hours. Do not use saline solutions or aluminum-containing intravenous sets. When used in a combination regimen, Eloxatin is typically administered before 5-fluorouracil.
- Missed Dose: If a dose is missed, the patient should notify their doctor, home caregiver, or treatment clinic immediately.
Adverse Reactions:
- Common Adverse Reactions:
  - Peripheral sensory neuropathy (e.g., numbness, tingling, cold sensitivity)
  - Nausea and vomiting
  - Diarrhea
  - Fatigue
  - Decreased blood cell counts (e.g., anemia, leukopenia)
- Serious Adverse Reactions:
  - Hypersensitivity reactions (e.g., anaphylaxis)
  - Posterior reversible encephalopathy syndrome (PRES)
  - Interstitial lung disease, or pulmonary fibrosis
  - Rhabdomyolysis
Contraindications: Hypersensitivity to oxaliplatin or any component of the product.
Precautions:
- Neuropathy: May be exacerbated by cold temperatures; avoid exposure to cold.
- Hematologic Monitoring: Regular blood counts are recommended due to potential myelosuppression.
- Renal Function: Use with caution in patients with impaired renal function.
- Pregnancy Category: Category D (positive evidence of risk).

Eloxatin Interactions

Cisplatin: Concurrent use may increase the risk of nephrotoxicity.
Phenytoin: May reduce the efficacy of phenytoin; monitor serum levels.
Live Vaccines: Avoid use during treatment due to potential for severe infection.
Other Chemotherapeutic Agents: Use with caution; consult prescribing information for specific interactions.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.