Deflazacort｜Inflammatory｜HongKong DengYue Medicine

Deflazacort Application Scope

Deflazacort is a corticosteroid used to treat various conditions, including:

• Duchenne Muscular Dystrophy (DMD)

• Inflammatory and autoimmune disorders

• Allergic reactions

• Certain cancers​

Deflazacort Characteristics

Ingredients

• Active Ingredient: Deflazacort

• Inactive Ingredients: Vary by manufacturer; consult specific product labeling for details​

Properties

• Class: Glucocorticoid

• Mechanism of Action: Anti-inflammatory and immunosuppressive effects​

Packaging Specification

• Tablets: Packaged in blister packs or bottles

• Oral Suspension: Supplied in bottles with dosing syringe​

Storage

• Store at room temperature, away from moisture and heat.

• Keep the medication in its original container, tightly closed, and out of reach of children.

• Dispose of any unused suspension after 1 month.

Expiry Date

• Refer to the packaging for the expiration date.​

Executive Standard

• Complies with regulatory standards set by health authorities; specific standards may vary by country.​

Approval Number

• Varies by country and regulatory agency; consult local regulatory resources for specific approval numbers.​

Date of Revision

• Refer to the latest prescribing information or package insert for the date of the most recent revision.​

Manufacturer

• Multiple manufacturers produce Deflazacort; refer to the product packaging for specific manufacturer information.​

Guidelines for the Use of Deflazacort

Dosage and Administration

• General Administration: Administer with or without food.

• Tablets: Can be swallowed whole or crushed and mixed with applesauce; consume immediately.

• Oral Suspension: Shake well before use; measure with provided dosing syringe; mix with juice (excluding grapefruit juice) or milk and consume immediately.

• Dosage Adjustments: When used with moderate or strong CYP3A4 inhibitors, reduce the Deflazacort dose to one-third of the recommended dosage. ​

Adverse Reactions

Common side effects include:

• Increased appetite

• Weight gain

• Increased body hair growth

• Sleep disturbances

• Cold-like symptoms

• Frequent urination

• Changes in body fat distribution​

Serious side effects may include:

• Severe allergic reactions

• Adrenal insufficiency

• Cushing’s syndrome

• High blood sugar

• High blood pressure

• Mood changes

• Osteoporosis

• Vision problems

• Severe skin reactions

• Slowed growth in children

• Muscle problems

• Blood clots

Contraindications

• Known hypersensitivity to Deflazacort or any of its components.

Precautions

• Avoid live vaccines during treatment and for at least 4 to 6 weeks before starting Deflazacort.

• Monitor for signs of infection; Deflazacort may suppress immune response.

• Use caution in patients with a history of gastrointestinal ulcers or other digestive issues.

• Long-term use may lead to osteoporosis; monitor bone density.

• May cause mood or behavioral changes; monitor patients for psychiatric symptoms.

• Regular eye examinations are recommended during prolonged therapy.

Deflazacort Interactions

Drug Interactions

• CYP3A4 Inhibitors: Drugs like clarithromycin, fluconazole, diltiazem, verapamil, and grapefruit juice can increase Deflazacort levels; dose adjustment may be necessary.

• CYP3A4 Inducers: Drugs like rifampin, carbamazepine, and phenytoin can decrease Deflazacort efficacy; concurrent use is not recommended.

• Neuromuscular Blockers: Concurrent use may increase the risk of acute myopathy.

Note:

• If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
• It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.