Cidofovir Injection Application Scope

Cidofovir is an antiviral medication primarily used for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS).

Cidofovir Injection Characteristics

Ingredients: Cidofovir.
Properties: It is an antiviral agent that inhibits viral DNA replication by selectively inhibiting viral DNA polymerases.
Specification: Available as an intravenous solution.
Packaging Specification: Specific packaging details should be referred to in the official prescribing information.
Storage: Store at controlled room temperature, away from light.
Expiry Date: Refer to the packaging for the specific expiry date.
Executive Standard: Refer to the official prescribing information for detailed standards.
Approval Number: Refer to the official prescribing information for approval details.
Date of Revision: Refer to the official prescribing information for the revision date.
Manufacturer: Gilead Sciences.

Guidelines For The Use Of Cidofovir Injection

Dosage and Administration:

Induction Treatment: Administer 5 mg/kg body weight as an intravenous infusion over 1 hour, once weekly for two consecutive weeks.
Maintenance Treatment: Starting two weeks after induction, administer 5 mg/kg body weight intravenously over 1 hour, once every two weeks.
Administration Requirements: Prior to each dose, administer 1 liter of normal saline intravenously over 1 to 2 hours. If tolerated, a second liter may be given over 1 to 3 hours at the start or immediately after the cidofovir infusion. Concomitant administration of oral probenecid is recommended to reduce nephrotoxicity.

Adverse Reactions:

Nephrotoxicity: Renal impairment is a significant risk; monitor renal function closely.
Neutropenia: Decreased neutrophil counts may occur; regular blood counts are advised.
Ophthalmic Issues: Potential for uveitis and decreased intraocular pressure.
Other Effects: Nausea, vomiting, headache, and hair loss have been reported.

Contraindications:

Hypersensitivity: Contraindicated in patients with known hypersensitivity to cidofovir or probenecid.
Renal Impairment: Not recommended for patients with existing renal dysfunction.
Concomitant Nephrotoxic Drugs: Avoid use with other nephrotoxic agents.

Precautions:

Hydration and Probenecid: Ensure adequate hydration and administer probenecid as prescribed to mitigate nephrotoxic risks.
Laboratory Monitoring: Regular renal function tests and complete blood counts are essential during treatment.
Pregnancy Category: Category D; may cause harm to the fetus. Use only if the potential benefit justifies the potential risk to the fetus.

Cidofovir Injection Interactions

Drug Interactions:

Nephrotoxic Agents: Concurrent use with other nephrotoxic drugs (e.g., amphotericin B, foscarnet, IV aminoglycosides, vancomycin, tacrolimus, NSAIDs) may increase the risk of renal toxicity.
Probenecid: Cidofovir must be administered with probenecid, which inhibits renal tubular secretion, reducing nephrotoxicity.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine.
It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.