Ifupinostat Application Scope

It is indicated for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) who have previously received at least two lines of systemic therapy. This targeted therapy offers a novel option for patients with limited treatment choices, aiming to inhibit tumor growth and improve clinical outcomes in this difficult-to-treat population.

Ifupinostat Characteristics

Ingredients: Ifupinostat Hydrochloride
Properties: First-in-class dual HDAC & PI3Kα inhibitor
Packaging Specification: 20.6 mg (lyophilized powder for injection)
Storage: 2–8 °C, protect from light, do not freeze
Expiry Date: Refer to product label (commonly 24–36 months)
Executive Standard: NMPA-approved chemical drug (Class 1) standard
Approval Number: NMPA conditional approval (2025)
Date of Revision: See the latest package insert
Manufacturer: Guangzhou BeBetter Medicine Co., Ltd.

Guidelines for the Use of xxx

Dosage and Administration:
- Recommended Dose: 18.5 mg/m²
- Administration: Days 1, 3, 5, 8, 10, 12 of each cycle until progression or intolerance
- Missed Dose: Follow the physician’s instructions; do not double-dose
Adverse Reactions:
- Common Adverse Reactions:
  - Thrombocytopenia
  - anemia
  - neutropenia
  - fatigue
  - nausea
- Serious Adverse Reactions:
  - Severe cytopenia
  - infection
  - bleeding
Contraindications: Hypersensitivity to components, severe uncorrected myelosuppression
Precautions:
- Monitor CBC
- liver/renal function
- infection signs
- use contraception during and after treatment

Ifupinostat Interactions

It may interact with strong CYP enzyme inhibitors or inducers, which can affect its metabolism and plasma levels.
Additionally, concurrent use with other myelosuppressive or anticoagulant medications can increase the risk of hematologic toxicity or bleeding.
Close monitoring of blood counts and careful management of co-administered drugs are recommended to ensure patient safety.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.