Avacopan Application Scope

Avacopan, marketed under the brand name Tavneos, is an orally administered complement 5a receptor (C5aR) antagonist used as an adjunctive treatment for adults with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).

avacopan

Avacopan Characteristics

Ingredients: Each capsule contains 10 mg of avacopan.
Properties: Tavneos is a complement 5a receptor antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a, thereby blocking C5a-mediated neutrophil activation and migration.
Specification: Hard capsules for oral administration, each containing 10 mg of Tavneos.
Packaging Specification: Bottles containing 180 capsules.
Storage: Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
Expiry Date: Refer to the packaging for the expiration date.
Executive Standard: Approved by the U.S. Food and Drug Administration (FDA) in 2021.
Approval Number: NDA 214487.
Date of Revision: October 2021.
Manufacturer: ChemoCentryx, Inc.

Guidelines for the Use of Avacopan

Dosage and Administration: The recommended dosage is 30 mg (three 10 mg capsules) taken orally twice daily with food.
Adverse Reactions: Common adverse reactions include nausea, headache, decrease in white blood cell count, upper respiratory tract infection, diarrhea, vomiting, and nasopharyngitis.
Contraindications: There are no listed contraindications.
Precautions: Monitor liver function tests during treatment. Advise patients to avoid grapefruit and grapefruit juice, as they can increase Tavneos concentrations.

Avacopan Interactions

Drug Interactions: Avacopan is a moderate inhibitor of CYP3A4 and may increase plasma concentrations of concomitant medications that are CYP3A4 substrates, such as alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, sirolimus, and tacrolimus.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from HongKong DengYue Medicine. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.