Akynzeo Application Scope

A fixed-dose combination antiemetic used to prevent chemotherapy-induced nausea and vomiting.

Characteristics

Ingredients:
- 300 mg of netupitant
- 0.5 mg of palonosetron
Properties: A selective neurokinin-1 (NK₁) receptor antagonist.
Packaging Specification: Available as a single-dose capsule in a blister pack.
Storage: Store capsules at room temperature, between 20°C to 25°C (68°F to 77°F).
Expiry Date: Refer to the packaging for the specific expiration date.
Executive Standard: Approved under FDA New Drug Application (NDA) 205718.
Approval Number: FDA approval granted on October 10, 2014.
Date of Revision: February 2023.
Manufacturer:Helsinn Therapeutics (U.S.), Inc.

Dosage and Administration:
- Capsules: One capsule (300 mg netupitant/0.5 mg palonosetron) taken orally approximately 1 hour before the start of chemotherapy.
- Injection: Administered intravenously over 30 minutes, starting 30 minutes before chemotherapy.
Adverse Reactions: Common side effects include headache, fatigue, constipation, and erythema.
Contraindications: None known.
Precautions:
- Hypersensitivity reactions, including anaphylaxis, have been reported with palonosetron.
- Serotonin syndrome has been reported, especially with concomitant use of serotonergic drugs.

Drug Interactions:
- Netupitant is a moderate inhibitor of CYP3A4; avoid concomitant use with strong CYP3A4 inducers or substrates.
- Dexamethasone doses should be reduced when given with Akynzeo.
Generic Name/Brand Name: Netupitant and palonosetron / Akynzeo
Indications: Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including highly emetogenic chemotherapy.
Dosage Form: Oral capsule
Specification: 300 mg netupitant / 0.5 mg palonosetron, capsules

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.