Why Lazcluze Is The Nemesis In The Treatment Of Non-Small Cell Lung Cancer？

Lazcluze is a cancer medicine used to treat adults with advanced non-small cell lung cancer (NSCLC) who have not been treated before.

It is used in people whose cancer cells have certain mutations (changes) in the epidermal growth factor receptor (EGFR) gene: exon 19 deletion or exon 21 L858R substitution mutation.

Lazcluze is used in combination with another cancer medicine, amivantamab.

About Non-Small Cell Lung Cance

The main subtypes of NSCLC are adenocarcinoma, squamous cell carcinoma and large cell carcinoma.

Among the most common driver mutations in NSCLC are alterations in EGFR, which is a receptor tyrosine kinase controlling cell growth and division.

EGFR mutations are present in 10 to 15 percent of Western patients with NSCLC with adenocarcinoma histology and occur in 40 to 50 percent of Asian patients.

EGFR ex19del or EGFR exon 21 L858R mutations are the most common EGFR mutations.

The five-year survival rate for patients with advanced NSCLC and EGFR mutations treated with EGFR TKIs is less than 20 percent and between 25-32 percent of patients receiving the current first-line standard of care, osimertinib, do not survive long enough to reach second-line treatment.

Efficacy And Safety

Efficacy was evaluated in MARIPOSA (NCT04487080), a randomized, active-controlled, multicenter trial of 1074 patients with exon 19 deletion or exon 21 L858R substitution mutation-positive locally advanced or metastatic NSCLC and no prior systemic therapy for advanced disease.

Patients were randomized (2:2:1) to receive lazertinib in combination with amivantamab, osimertinib monotherapy, or lazertinib monotherapy until disease progression or unacceptable toxicity.

What Are The Possible Side Effects Of Lazcluze?

• Blood clot problems

Blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) are serious, but common, and may lead to death.

Your healthcare provider will start you on medicine to prevent blood clots for the first four months of treatment.

Tell your healthcare provider right away if you have any signs and symptoms of blood clots, including swelling, pain or tenderness in the leg, sudden unexplained chest pain, or shortness of breath.

• Lung problems

LAZCLUZE may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you get any new or worsening lung symptoms, including shortness of breath, cough, or fever.

• Skin problems

LAZCLUZE may cause severe rash including redness, raised acne-like bumps, itching, and dry skin. You may use alcohol-free (such as isopropanol-free, ethanol-free) moisturizing cream to reduce the risk of skin problems.

Limit sun exposure during and for 2 months after treatment with LAZCLUZE. Wear protective clothing and use sunscreen. Tell your healthcare provider right away if you get any skin reactions.

Clinical Trial Results

The MARIPOSA trial was a global, multicenter, randomized, controlled Phase III study that enrolled 1,074 patients with advanced NSCLC carrying the EGFR exon 19 deletion or exon 21 L858R mutation.

Results showed that the median progression-free survival was 23.7 months in the Lazcluze and amivastamavir combination therapy group, compared with 16.6 months in the ositinib monotherapy group, a 30 percent risk reduction.

In addition, the median overall survival in the combination therapy group is expected to exceed that of the ositinib group by more than one year, demonstrating a statistically significant survival advantage.

About DengYueMed – HK Drug Wholesale Distributor

As a legally compliant drug import and export company, DengYueMed is certified by the pharmacy & poisons board of Hong Kong — you can verify our qualification on their official website.

Our efforts to improve the affordability of Lazertinib drug aim to ensure that more patients can benefit from this important medication.

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