How Much Do You Know About Niktimvo’s Healing Properties?

Niktimvo (axatilimab-csfr) is a prescription medicine used to treat chronic graft-versus-host disease (cGVHD) if you have received at least 2 prior treatments and they have not worked.

Niktimvo works by targeting the drivers of inflammation and fibrosis that are seen in chronic GVHD, it is the first approved anti-CSF-1R antibody. It can be used in patients who weigh at least 88.2 pounds (40 kg).

How Does Niktimvo Work? 

Niktimvo is a monoclonal antibody that works by binding and blocking a receptor called colony-stimulating factor-1 receptors (CSF-1R) on cells in the immune system (monocytes and macrophages).

By blocking CSF-1R, Niktimvo reduces the levels of monocytes and monocyte-derived macrophages, which are proinflammatory and profibrotic, and inhibits the activity of pathogenic macrophages in tissues.

Related Indications

Niktimvo™ (axatilimab-csfr) is a prescription medicine approved by the FDA that is used to treat adults and children who weigh at least 88.2 pounds (40 kg) with chronic graft-versus-host disease (cGVHD) after receiving at least 2 prior treatments (systemic therapy) and they did not work.

It is not known if Niktimvo is safe and effective in adults and children weighing less than 88.2 pounds (40 kg).

What Should I Be Aware Of Before Taking This Medicine?

Before receiving Niktimvo, tell your healthcare provider about all of your medical conditions, including if you have or have had liver problems. 

Pregnancy

Tell your healthcare provider if you are pregnant or plan to become pregnant as Niktimvo may harm your unborn baby. Females who are able to become pregnant: 

Your healthcare provider should do a pregnancy test before you start treatment with Niktimvo. 

You should use an effective method of birth control during your treatment and for 30 days after your last dose of Niktimvo. 

Talk to your healthcare provider about birth control methods that you can use during this time. 

Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Niktimvo.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed as it is not known if Niktimvo passes into your breast milk.

Do not breastfeed during treatment and for 30 days after your last dose of this medicine. 

Dose Information And Storage

The recommended Niktimvo dosage is 0.3 mg/kg (maximum 35 mg) every 2 weeks in adult and pediatric patients weighing 40 kg and above.

Niktimvo is available as	Storage of information
9 mg/0.18 mL solution in a single-dose vial 22 mg/0.44 mL solution in a single-dose vial 50 mg/mL solution in a single-dose vial	Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze or shake.

What Are The Possible Side Effects?

• infections 
• low red blood cell count (anemia)
• muscle, bone, or joint pain
• increased blood level of pancreatic enzymes
• increased blood level of liver enzymes
• decreased blood level of phosphate
• low energy
• increased blood level of calcium
• increased blood level of a muscle enzyme
• increased blood level of a bone enzyme
• nausea
• headache
• diarrhea
• cough
• fever
• shortness of breath

Safety Profile

While Niktimvo has demonstrated significant efficacy, its safety profile includes several notable adverse effects. In the AGAVE-201 trial:

Serious adverse reactions occurred in 44% of patients, with infections (unspecified pathogen, 14%), viral infections (14%), and respiratory failure (5.1%) being the most common.

Infusion-related reactions (IRRs) were reported in 18% of patients, with Grade 3/4 reactions in 1.3%. To mitigate these, premedication with antihistamines and antipyretics is recommended for patients with a history of IRRs.

Dose interruptions due to adverse reactions occurred in 44% of patients, while 10% discontinued treatment permanently.

About DengYueMed – HK Drug Wholesale Distributor

As a legally compliant drug import and export company, DengYueMed is certified by the pharmacy & poisons board of Hong Kong — you can verify our qualification on their official website.

Our efforts to improve the affordability of Niktimvo drug aim to ensure that more patients can benefit from this important medication.

HK DengYue provides detailed medicine information, transparent pricing, and responsive support to ensure a smooth and reliable buying experience.

Feel free to reach out anytime to discuss your needs or ask questions about the medicine.

We welcome you to contact us for a consultation.