Sparsentan Application Scope

FILSPARI is a first-in-class, dual endothelin angiotensin receptor antagonist (DEARA). It blocks endothelin type A (ETA) and angiotensin II type 1 (AT1) receptors, reducing proteinuria and slowing kidney function decline in IgA nephropathy.

Indication:

Primary IgA nephropathy (IgAN): In adults at risk of rapid disease progression.

Sparsentan Characteristics

Ingredients: Active ingredient: Sparsentan
Excipients: microcrystalline cellulose, povidone, magnesium stearate, etc.
Properties: Film-coated oral tablets.
Packaging Specification: 200 mg tablets, 90 tablets/bottle.
Storage: Store at 20–25°C. Protect from moisture.
Expiry Date: As indicated on package.
Executive Standard: FDA approval standard.
Approval Number: Per local authority.
Date of Revision: As indicated in insert.
Manufacturer: Travere Therapeutics, Inc.

Guidelines for the Use of FILSPARI

Dosage and Administration:
- Recommended Dose: 400 mg orally once daily.
- Administration: Swallow whole, with or without food.
- Missed Dose: If a dose is missed, take as soon as remembered unless close to next dose. Do not double dose.
Adverse Reactions:
- Common Adverse Reactions:
  - Peripheral edema
  - Hypotension, dizziness
  - Hyperkalemia
  - Anemia, fatigue
- Serious Adverse Reactions:
  - Hepatotoxicity (elevated liver enzymes)
  - Embryo-fetal toxicity (contraindicated in pregnancy)
Contraindications:
- Pregnancy (high teratogenic risk)
- Hypersensitivity to sparsentan or excipients
Precautions:
- Monitor liver function and serum potassium regularly
- Teratogenic risk → use only under REMS program in the U.S.
- Use with caution in patients with hypotension or renal impairment

Sparsentan Interactions

Avoid use with strong CYP3A inhibitors/inducers
Risk of hyperkalemia when combined with potassium-sparing diuretics or RAAS inhibitors

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.