Ganovo Application Scope

Ganovo is an orally administered hepatitis C virus (HCV) NS3/4A protease inhibitor. It was the first domestically developed direct-acting antiviral (DAA) for HCV approved in China.

ganovo

Characteristics

Ingredients: Danoprevir

Properties: Danoprevir is a potent inhibitor of the HCV NS3/4A protease, which is essential for viral replication.
Packaging Specification: Typically supplied in blister packs containing 100 mg film-coated tablets.

Storage: Store in a cool, dry place away from direct sunlight.
Expiry Date: Refer to the packaging for the specific expiration date.
Executive Standard: Manufactured in compliance with Good Manufacturing Practices (GMP)
Approval Number: Approved by the National Medical Products Administration (NMPA) of China
Date of Revision: Refer to the latest prescribing information leaflet for the date of revision.
Manufacturer: Ascletis Pharma Inc., China.

Guidelines for the Use of Ganovo

Dosage and Administration:
- The recommended dosage is 100 mg taken orally twice daily
- In combination with other antiviral agents such as ritonavir and peginterferon alfa-2a plus ribavirin
- Depending on the specific treatment regimen

Adverse Reactions:
- Common side effects may include fatigue, headache, nausea, and diarrhea.
- Serious adverse reactions are rare but can include liver enzyme elevations.
Contraindications: Contraindicated in patients with known hypersensitivity to danoprevir or any component of the formulation.
Precautions:
- Use with caution in patients with moderate to severe hepatic impairment.
- Regular monitoring of liver function tests is recommended during treatment.

Ganovo Interactions

Drug Interactions:
- Danoprevir is metabolized by the CYP3A4 enzyme
- Co-administration with strong CYP3A4 inhibitors or inducers may affect drug levels
- It is often administered with ritonavir to boost its plasma concentration
- Careful consideration should be given when combining with other medications metabolized by CYP3A4

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.