Verzenio Application Scope

Verzenio (abemaciclib) is a prescription medicine used to treat Hormone Receptor (HR)-positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer in specific situations.

Verzenio Characteristics

Ingredients: Abemaciclib
Properties: A selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6)
Packaging Specification: Tablets available in strengths of 50 mg, 100 mg, 150 mg, and 200 mg
Storage: Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F)
Expiry Date: Refer to the expiry date printed on the packaging
Executive Standard: Complies with FDA regulations for oncology medications
Approval Number: NDA 208716
Date of Revision: October 2021
Manufacturer: Eli Lilly and Company

Guidelines for the Use of Verzenio

Dosage and Administration:
- Recommended Dose:
  - In combination with endocrine therapy (tamoxifen or an aromatase inhibitor): 150 mg orally twice daily.
  - In combination with fulvestrant: 150 mg orally twice daily.
  - As monotherapy: 200 mg orally twice daily.
- Administration:
  - May be taken with or without food.
  - Swallow tablets whole; do not chew, crush, or split.
  - If a dose is missed, take the next dose at the scheduled time; do not take two doses at once.
- Missed Dose:
  - If a dose is missed, take the next dose at the scheduled time.
  - Do not take two doses at once to make up for a missed dose.
Adverse Reactions:
- Common Adverse Reactions:
  - Diarrhea
  - Neutropenia
  - Fatigue
  - Anemia
  - Nausea
  - Leukopenia
  - Headache
- Serious Adverse Reactions:
  - Infections
  - Pneumonitis
  - Cardiac events (e.g., heart failure)
  - Gastrointestinal perforation
Contraindications:
- Pregnancy: Verzenio can cause harm to a developing fetus. It is not recommended for use during pregnancy. Effective contraception is required during treatment and for at least 3 weeks after the last dose.
- Breastfeeding: It is not recommended to breastfeed while taking Verzenio and for at least 3 weeks after the final dose, as it is not known if the drug passes into breast milk.
Precautions:
- Your doctor will monitor your blood cell counts and liver function before and during treatment.
- Report any signs of infection (e.g., fever, chills) or diarrhea to your doctor immediately.
- Inform your doctor of all other medications you are taking, including over-the-counter drugs and herbal supplements, due to potential interactions.

Verzenio Interactions

Drug Interactions:
- Strong CYP3A inhibitors (e.g., ketoconazole) may increase abemaciclib plasma concentrations.
- Strong CYP3A inducers (e.g., rifampin) may decrease abemaciclib plasma concentrations.
- Avoid co-administration with strong CYP3A inhibitors or inducers.
Food Interactions:
- No significant food interactions identified.

Note:

If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYue Medicine.
This content is for reference only. Prescription drugs must be used under a doctor’s guidance and purchased from authorized sources.