Nurtec ODT (Rimagipam): The Dual-Action Oral Dissolving Tablet That Revolutionizes Migraine Treatment
Migraines afflict more than one billion people worldwide, and their attacks of severe headache, light sensitivity and nausea often bring patients’ lives to a halt.
In 2020, the FDA approved Nurtec ODT (rimegepant).
This orally dissolvable tablet (ODT) is quickly becoming a market focal point due to its unique dual action, providing both rapid relief from acute attacks and prevention of episodic migraines.
As of 2025, it has become the #1 prescribed brand in its class.
Clinical Results: Fast-Acting, Long-Lasting Relief
Nurtec ODT’s breakthrough lies in its mechanism of targeting CGRP (calcitonin gene-related peptide) to achieve symptom control by blocking this key protein that triggers migraine pain signalling.89 Pivotal clinical trials have shown:
Acute treatment: 59.3% of patients experienced pain relief within 2 hours of taking the drug (43.3% in the placebo group), and 21.2% achieved complete pain freedom (10.9% in the placebo group).
PREVENTIVE ACTION: When taken every 48 hours, the number of patient-monthly migraine days was reduced by 4.3 days after 12 weeks, and the number of days of moderate or greater headache was halved in nearly half of the patients.
No need to drink water: tablets dissolve in seconds on the tongue, making them suitable for use during sudden attacks.
Patient Experience And Real-Life Examples
“As a mother of two, I can’t function when I have a migraine attack. The fast onset of Nurtec ODT has allowed me to get back to my family quickly.” — Patient Jenna B shared.
In similar cases, 86% of patients did not need additional rescue medication within 24 hours of a single dose.
Safety: well tolerated, but be wary of allergic reactions
Common side effects include only nausea (acute treatment) and dyspepsia (prophylactic use).
However, caution is required:
SEVERE ALLERGIC REACTIONS: may be delayed for several days, such as swelling of the throat or rash, and require immediate medical attention.
Dosage restrictions: no more than 1 tablet in 24 hours and no more than 18 tablets in 30 days (safety not established).
Economic Burden And Assistance Programs
The high price of Nurtec ODT (approximately $1,029 retail for an 8-tablet pack) is a major concern for patients. To alleviate the burden:
Commercially insured patients: a $0 out-of-pocket discount (up to $7,000 annual benefit) is available through the Nurtec OneSource program.
Uninsured: 80% savings on a prescription discount card that reduces the price of a single box to about $850.
Medicare coverage: 75% of Medicare D plans cover the drug, subject to meeting the deductible.
Nurtec ODT Future Outlook: Patents And Market Competition
There are currently no generics for Nurtec ODT (patent until 2039), but it has a solid lead in the CGRP antagonist space.
While its counterparts, Ubrelvy and Qulipt, have similar mechanisms, Nurtec ODT is the only agent that combines therapeutic and preventive effects.
Conclusion
From the lab to the medicine cabinet, Nurtec ODT offers unprecedented control for migraine sufferers with its speed, convenience, and dual action.
As more real-world data accumulates, it may become the gold standard for migraine management worldwide.
About DengYueMed – HK Drug Wholesale Distributor
As a legally compliant drug import and export company, DengYueMed is certified by the pharmacy & poisons board of Hong Kong — you can verify our qualification on their official website.
Our efforts to improve the affordability of Rimegepant drug aim to ensure that more patients can benefit from this important medication.
HK DengYue provides detailed medicine information, transparent pricing, and responsive support to ensure a smooth and reliable buying experience.
Feel free to reach out anytime to discuss your needs or ask questions about the medicine. We welcome you to contact us for a consultation.
