Thiamazole Cream | Anti Hyperthyroidism

Thiamazole Cream Application Scope

Thiamazole Cream, this new and special drug is effective in managing hyperthyroidism symptoms, especially before thyroid subtotal resection or radioactive iodine therapy, and for patients who cannot undergo surgery.

Thiamazole Cream Characteristics

• Ingredients: Thiamazole (1-Methyl-1,3-dihydro-2H-imidazole-2-thiol)
• Properties: White emulsion-type cream.

Guidelines For The Use Of Thiamazole Cream

Dosage and Administration: 

• Use a precise dose pump to press out 0.1g of the cream (containing 5mg of Thiamazole) per application. Apply evenly to the surface of the thyroid area on the front of the neck (from the Adam’s apple to the upper chest, applying to the areas where thyroid enlargement is prominent). Gently massage the applied area with your fingers for 3-5 minutes to allow the drug to penetrate the thyroid.
• For patients previously using oral Thiamazole tablets (10mg per dose, 3 times daily), you can switch to this cream with a dose of 0.2g per application (containing 10mg Thiamazole), applied 3 times daily. This has a clinical effect similar to that of the oral tablet.

Adverse Reactions:

• Common local adverse reactions include itching, burning, tightness, scaling, and papules. These reactions occur in approximately 19.4% of patients, though they are generally mild and self-limiting.
• Systemic adverse reactions are rare and mainly include liver function abnormalities and leukopenia, with an incidence rate of about 1.4%. These reactions are less common compared to oral administration.

Thiamazole Cream Medication Limitations

Contraindications: Contraindicated for individuals who are hypersensitive to Thiamazole or for those with skin lesions at the application site.

Precautions:

• To reduce the occurrence of local adverse reactions:

1. keep the neck area clean and dry.
2. Apply the cream gently and avoid using soap with a high pH on the treated area.
3. If a severe local reaction occurs, consult with a healthcare provider to possibly suspend the use of the product and seek treatment from a dermatologist.
4. Though systemic side effects are rare, it is recommended to regularly check liver function and blood counts. If serious systemic reactions occur, immediately stop the medication and provide symptomatic treatment.

• Caution should be taken when using the cream for patients with liver function abnormalities or low white blood cell counts.
• Children should not use this product, as there is insufficient research available on its safety in children.
• Pregnant women should use the cream cautiously after fully considering the benefits and risks. It can pass through the placenta and may harm the fetus.
• In the case of correct and reasonable use, this product is an effective drug for the treatment of hyperthyroidism in pregnant women. As the pregnancy progresses, the condition of pregnant women with hyperthyroidism may be reduced, and the dose of the drug can be reduced.
• This product is contraindicated during breastfeeding due to potential secretion into breast milk.

Thiamazole Cream Interactions

• Cross-allergy may occur when combined with other thionamide-based anti-thyroid drugs.
• Co-administration with anticoagulants may enhance the anticoagulant effect.
• High iodine foods or drugs may worsen hyperthyroidism, leading to increased dosages or prolonged usage.
• Combining with drugs that reduce granulocytes may increase the risk of granulocyte reduction.

Note: If there is a new packaging for the drug, the new packaging shall prevail. The above information is sourced from DengYueMed. It is only for internal discussion among medical staff and does not serve as a basis for medication. For specific medication guidelines, please consult the attending physician.